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Sunday, October 16, 2016

An Omega-3 Fatty Acid (DHA) Found to Prevent Onset of Lupus in Mice │ Depression and Stress Affect Us Like Ageing │ Nicotine Thought Able to Increase Certain Brain Receptors

It was something like 12:07 a.m. when I made it to bed last night ─ there are just so many T.V. series to watch now that we have an Android TV Box.

The last show I watched was the first episode of a series I had never even heard of called Quarry.  Now I may be hooked.

Darned if I can remember now just when it was that I had my first break in sleep overnight and used the bathroom, nor just what time it was that I rose for the day.

My youngest step-son Pote was up ─ his overnighted girlfriend must have left earlier this morning.

I got to work on the post I have 'on the go' at one of my hosted websites, but I didn't want to get too drawn into it because I wanted to get out and make my weekly beer hike ─ a four-mile or so round-trip involving the government liquor store at 108th Avenue & King George Boulevard here in Whalley.

Very shortly after 9:00 a.m., my wife Jack showed up.

I finished up what I felt I could squeeze in concerning that post while Jack was occupied with some cleaning-up in the kitchen ─ Pote and his girlfriend are slobs.

Jack even gave the kitchen floor a mopping.

Soon her eldest son Tho was up from bed.

And then the next I knew, they were all readying and left in Jack's car.  It seems that Tho really was going to be getting the car back that the police had impounded last weekend after catching him driving it when his licence had been suspended.

I had initially thought that Pote was being driven to work at Guildford, but of course he was needed to actually drive Tho's car home ─ the cops would never turn the car over to Tho to drive himself without a valid driver's licence.

I just wonder what this whole fiasco is costing?  And has Jack assumed some of the cost, for that affects me and our ability to keep abreast of bills we need to pay?

My younger brother Mark arrived home from his girlfriend Bev's home shortly after 10:00 a.m. ─ Jack and her two sons had already gone.

And soon enough, I heard Tho's car; and into the house came Tho and Pote.

But no Jack.

I decided that I had better ready myself for my hike ─ maybe I could slip away before she was home.

I did a fabulous job of it ─ I snuck out without anyone here realizing I was going anywhere.  It was 11:06 a.m.

The day was heavily overcast, with a bit of blustering wind.  Attempts to rain prevailed, but none of it ever became serious.

I had two letters to mail at Pearl Photo/Canada Post in Surrey Place (Central City), the halfway point of my hike.  One item was a credit card payment due next Friday; the other was an application for MSP premium assistance for Pote.

He turns 19 next month and will thereafter no longer qualify as my dependant, and thus an account will be set up for him personally.  But his Net Income last year was below $9,000, and this will qualify him for premium-free coverage until his taxable income gets higher.

The full rate per month is presently $75, but his income will have to climb over $30,000 before he gets tagged with that.  He will have free coverage until his Net Income exceeds $22,000; at that point, he would be paying $12.80 per month.

From $22,000, the reduced rate keeps escalating with every $2,000 jump in Net Income until that $30,000 cap entirely disqualifies him from any premium assistance. 

But I have gotten off track.

I really have nothing to report concerning my venture, except having a bit of a friendly exchange with an Aboriginal Canadian chap in the liquor store ─ he and his compadre were already rather 'well-oiled.'

They decided on a half-dozen of the same strong (8% alcohol) beer I was buying, and joined me at the till.  Only the one fellow ever said anything, but he was certainly not one to hold back ─ he was saying enough for the both of them.

The cashier was an Asian woman who might have been into her 40s, but very pleasant to look at (where my eyes are concerned).  The talkative fellow spoke up and said of her, "I'm going to have to call you Miss Yukon!"

Her eyes flew wide to me, and she threw a big smile, saying, "I guess I'm going to have to learn a new language!"

I rather like that gal ─ I frequently deal with her there.

I was back home no later than 12:38 p.m., so the trip took about 1½ hours.

Jack still was not here, but there were groceries that had not been there earlier, and Mark hadn't brought them ─ he had come home empty-handed.

He soon enough left for the afternoon, and I was having a quick, light breakfast/lunch here at my computer when she again made an appearance.

She announced that she was going to have a nap, and that is where matters are at this time of 2:16 p.m.

Before I move on, I want to post this old photo ─ the description beneath it is from the Google album where I have the scan saved:

That is my mother Irene Dorosh, but I can offer little else concerning the photo.

I do not recognize the setting.

Judging by how she looks, I would estimate the photo to have been taken in the late 1960s, or very early in the 1970s.
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Have you any experience with lupus?  Maybe you know someone who suffers from it, if you do not yourself have the condition.

Apparently this autoimmune disease can suddenly be triggered by a number of different things, such as the body's reactions to an infection, or even its response to certain medications.

Well, a study of mice has found that DHA (docosahexaenoic acid) ─ an omega-3 fatty acid ─ may be able to halt the triggering of the disease.

The researchers used just one known trigger in their experiments on the mice ─ they used "crystalline silica, a toxic mineral also known as quartz that's linked to human autoimmunity."

But the effect of DHA was so dramatic that the researchers are extrapolating broadly about DHA's potential to be able to stop the triggering of other autoimmune disorders.

Imagine!
Some common autoimmune disease include celiac disease, diabetes mellitus type 1, Graves disease, inflammatory bowel disease, multiple sclerosis, psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.
That quote is from Wikipedia.

Here is a report on that study, if you are interested:

Lupus is considered a genetic disease and is triggered not only by inhaling crystalline silica toxicants, but also by other environmental factors such as sun exposure. Quartz is the most common, and most dangerous, form of crystalline silica and is often found in the agriculture, construction and mining industries where workers can breathe in the mineral dust.

"Lupus is the body's immune system attacking itself and it can damage any part of the body including skin, joints and organs," said James Pestka, a University Distinguished Professor of food science and human nutrition, who also co-led the research with Bates and Harkema.
And:
"Cells in the lung can gobble up the silica, but it's so toxic, it kills these cells," Harkema said. "When they die, signals are sent out to the immune system that something is wrong. The body then produces such a strong response that it also starts to target healthy cells."
As you may know, a superb source of DHA is fish oil ─ preferably wild salmon, and not the farmed garbage.

A primary medication presently in use to treat lupus is Benlysta ─ but check out its incredibly wide-ranging list of side-effects that are provided over at Drugs.comBenlysta Side Effects

Benlysta has even killed people ─ some of whom did it to themselves via suicide as a result of the severe depression the drug induced.

Why do people keep turning to Mad Science when there are perfectly wholesome and harmless alternatives?

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Fish oil supplementation figures into this next item, too ─ it's one of the suggestions or recommendations offered to help offset the effects of depression and stress, which seem to have the same effect upon us as does ageing.

It's an interesting essay:

DrMicozzi.com

I will leave it to you to delve into ─ the reading is easy enough.

His study reference probably isn't something the average reader will much appreciate, though ─ over at eurekalert.orgResearchers identify genes linked to the effects of mood and stress on longevity.  

I am taking the recommended amount of fish oil (as Wild Salmon & Fish Oils), but thus far I am still taking just 4,000 I.U.s of vitamin D3 per day ─ not the 10,000 I.U.s. 

I am still on the fence.  

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Mice were used in the lupus study, and more mice were used in a study involving nicotine.

I'm pushed for time now, but the gist is that the mice given the highest amounts of nicotine in their drinking water seemed to increase the number of certain receptors in their brain ─ something that would prove vital where avoiding various kinds of dementia  is concerned.

The nicotine also helped the mice to naturally drop some weight because they just were not as hungry. 
...Low and medium doses of nicotine administered via drinking water, did not result in consistent blood nicotine levels and did not affect food intake, body weight or nicotinic receptor binding. Only the highest dose of nicotine tested in this study resulted in significant differences in these measures....
You can read some reports on the study for yourself:

PsyPost

NewsDog

Xtalks

EXPRESS.co.uk

I would be interested in finding out just what the equivalent amount of nicotine would be for a human to match the highest levels that were administered to the mice via their water.  I would have tried to see if this match-up was given, but I just don't have time.

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My wife Jack left shortly after 4:00 p.m. to return to Vancouver. I am to report to her if Tho uses his car, for she is concerned that he could face jail time if he is caught doing so again while under driving suspension.

She said that she might be back tomorrow. 

It is time for me to close out now with this 41-year-old journal entry from back when I was 26 years old, and living in a basement housekeeping unit in New Westminster.

The tiny unit was being rented in a house located on Ninth Street at Third Avenue.

My big plan of the day was to hike on out to my mother Irene Dorosh's Surrey home ─ she and her husband Alex had gone to Reno, and I was keeping a bit of an eye on the place.

It was also my main mailing address; and although the house now does not exist, its address was 12106 - 90th Avenue.

To hike there directly from my room would take about 1½ hours of fast walking. 

However, I was of late sometimes doubling that distance by traveling the King George Highway all the way to Newton's 72nd Avenue; and then taking to the railway tracks that cut across both it and the King George.  I would turn right onto those tracks, and then follow them until I arrived at the Surrey terminus of 90th Avenue at Holt Road, very close to Scott Road (120th Street).

My mother's home was just a half-dozen or so houses down 90th Avenue, on the right-hand side of the street.
THURSDAY, October 16, 1975

I got up to what looks like a rainy day at 3:30 a.m.  

To win a lottery and live and eat a good life!

Anyway, I do think I have a best-yet diet system worked out, and now that Thanksgiving's dinners are past, I shall try it out.

I shall leave for mom's via Newton in my first walk in the Panther boots at 5:30 a.m., in the downpour. 

At a bus stop by A&W some guy was busy puking.

I experienced the fact that the boots afflict my feet.

At mom's yesterday's mail was an Olympic ticket; today's was a letter from Ron.

About 8:45 a.m. I called and awoke Bill, as he last night requested; about 11:00 a.m. I lied down for some sleep, arising 12:30 p.m. to answer Cathy's phonecall; tomorrow morn she wanted me to do some babysitting, forgetting I must work at S.A.N.E.; anyway, she talked some while; she plans supper tomorrow for mom & Alex, and invited me if I could make it.

Bill phoned to see if I wanted a ride, but I declined ─ and got very wet!  I cannot now write clearly due to the cold.

I noticed new scribbling on my door; seems Norman came Tuesday, and wished me to be home the following day or else phone.

I am to watch some TV at Bill's, so I'll call him tonight.

I see my S.A.N.E. $50 cheque came.

I learned Norman left these parts last night. 

I watched 2 hours of TV, but am not yet warm.

Bill drove me home, bypassing Art's so he'll know where to find me tomorrow night for our trip to Nell's.

Bed at 9:15 p.m.
The A&W hasn't existed for years, but I think it was basically at the crest of the hill and on the left-hand side of the highway as one traveled the King George towards Whalley.  Perhaps around where 132nd Street intersects the highway ─ memory fails, alas.

The letter that arrived this day was from Ron Bain, an American pen-pal; it was an Olympic Lottery ticket that had come the day prior.

My old friend William Alan Gill also lived in New Westminster, but I cannot now say why he wanted me to phone and wake him up.

My nap was interrupted by a call from Catherine Jeanette Gunther, my younger brother Mark's girlfriend ─ the pair were renting a home together in Whalley.  Apparently my mother and Alex were due back the following day.

I only worked one day a week ─ generally Friday ─ at S.A.N.E. (Self Aid Never Ends), a New Westminster charitable organization that is now called Fraserside Community Services Society.

My hike back to my room would have been by the shorter direct route.  My old friend Norman Richard Dearing had been by on Tuesday ─ two days earlier ─ but I was only now noticing his scribble on my door.

Unfortunately, when I phoned him from Bill's bachelor suite when I went over there to watch some T.V., Norman's folks told me that he had left again to return upcountry where he was then living.

I must have been obligated to visit Art Smith the following day after I finished work at S.A.N.E.  Art was in his early 40s, married, and had three kids.  But he was always trying to have me hang out at the house to drink with him.

Bill was going to fetch me and spare me having to sit until into the a.m. at Art's home; but if we were going to visit my Aunt Nell Halverson's home off in Surrey, then that was only going to be a late night of drinking anyway!

I miss being young.
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