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Monday, July 6, 2015

Arthroscopic Knee Surgery to Reduce Pain ─ Avoid It! │ Study: Resveratrol Turns White Fat Into Desirable Beige Fat (in Mice)

While I was watching T.V. fairly early last evening, I suddenly noticed via the living room window that there seemed to be smoke all over the place here in our Surrey cul-de-sac.

Initially I thought that there might be a house-fire nearby, but there were never any sirens, and the smoke never thickened.

Then later I heard the news ─ the smoke is ruling the skies all over the Greater Vancouver area due to forest fires.

I got to bed by 11:30 p.m., and had the trending poor sleep due to high nighttime temperatures.

When I rose shortly after 8:00 a.m. this morning feeling as if I should be going to bed instead of rising for the day, I quickly saw that the smoky haze is prevalent.  A weather report on the radio announced that it would be sunny today with temperatures ranging from 28º Celsius to 32º Celsius, but the Sun would not be visible due to the smoke.

What good are cloud-like conditions if the heat is unabated, rain is impossible, and sunning is mainly unproductive?

Before I proceed further, though, I want to make solid note that much of my day was spent editing a December 16, 2011, post titled Bangkok Jam Restaurant Berkeley at My Retirement Dream ─ one of my six hosted websites.

Although both Canada Day (July 1) and the Fourth of July have passed, the Health Sciences Institute (HSI) put out a report on smart barbecuing to reduce the cancer-causing properties of seared meat.  They released the report on July 3:
Fourth of July weekend gives us all the opportunity to soak in one of our favorite summertime aromas -- steaks, burgers and chicken cooking on the grill.

Throwing some cold water on the charcoal, however, is all the bad news linking grilled meat to cancer. But if that's put a damper on your backyard gourmet grilling, I have some good news to report.

The problem comes when you grill meat at high temperatures, which causes an amino acid to react with sugar. This results in the formation of cancer-causing compounds called HCAs. And well-done meat has three and a half times as many HCAs as medium-rare.

And to make the problem even worse, thick commercial barbecue sauces containing added sugars actually cause another threefold increase in the amount of HCAs!

But now, a team of researchers from the Cancer Research Center of Hawaii has come up with an antidote that will actually improve the taste of what you're grilling in the bargain!

They found that marinating meats can reduce the amount of cancer-causing compounds in them by up to 99 percent.

Their recommendation is that you use half a cup of marinade for every pound of meat, with larger pieces perhaps requiring a bit more. And you don't need to do it for very long, either, to achieve the desired effect.

Another thing the Hawaiian team found was that these anti-cancer benefits are enhanced by the addition of certain herbs. These include basil, mint, rosemary, sage, savory, marjoram, oregano, and thyme, all of which contain a trio of powerful antioxidants.

Charring can also be prevented by cooking the meat at a medium-high temperature and flipping it often. And trimming off the fat can prevent another cancer-causing compound from forming in smoke when fat drips onto the coals.

And while I'm on the subject, there's one other hazard of grilling that can be avoided with just a little extra care. I'm talking about having a piece of wire break off from the brush you use to clean the grill and ending up with you or someone else swallowing it.

It might not happen often. But it can be quite serious when it does, possibly scratching your esophagus or puncturing your stomach or intestine. Recently, for example, a Connecticut woman had to undergo emergency surgery to remove a one-inch piece of metal from her gut. And this was two days after she accidentally ingested it in a burger cooked on her outdoor grill.

To avoid such an ordeal, experts recommend that you thoroughly rinse your grill after scrubbing it.

Happy grilling, and enjoy your 4th of July!
Well, I did a little research of my own, and learned that the Cancer Research Center of Hawaii study was made and published several years ago ─ at least as far back as 2008.

I don't mind good advice, but the impression being given in the HSI report is that the study was recent ("But now, a team of researchers...").  I think the phrasing was deliberate to give that impression.

The Health Sciences Institute are a member site of NewMarketHealth.com.

Dr. William Campbell Douglass II also released a couple of reports on July 3 ─ the first concerned arthroscopic knee surgery to reduce or alleviate chronic knee pain; and the second related to a method of turning regular body fat into healthier beige fat.

Let's look at the knee surgery report:

Read this BEFORE you go under the knife to fix your knee
Forget the one-armed bandit known as the slot machine. When surgeons want to hit the jackpot, they skip the arm and head straight for the leg -- specifically the knee, where the average arthroscopic knee surgery pays out $33,000.


With every single surgery the money pours down like rain on surgeons, anesthesiologists, nurses and of course on the hospitals themselves. Everyone's a winner with these procedures... well, everyone that is, except for YOU!

You're promised relief from the pain of a meniscus problem or osteoarthritis. But instead of that relief you get a raised risk for everything from clots to infection during the procedure, followed by the pain of recovery and rehab.

And when the dust settles, what do you have to show for it?

Zip... zilch... zero... NADA!

The best you can hope for, according to a new study, is three to six months of pain relief. After that, it's back to square one -- back to the same pain the operation was supposed to "fix."

Now, if you're battling the kind of pain these surgeons target, you might sign up for that surgery anyway if it would at least improve physical function.

Next to the pain itself, that's the worst part -- being hobbled, unable to get around and even forced to rely on a cane or walker.

But the new review of 18 studies finds the surgery is about as good for function as wishes and fairy dust.

There's ZERO improvement.

The surgery is a turkey, and the fact that there was a stack of 18 studies for the researchers to analyze shows the entire industry has known the truth all along.

They've known it... but they weren't about to let the gravy train come to a halt.

The researchers behind the new study say you're better off with just exercise, but don't take up running or even jogging just yet; that'll wreck your knees more than ever.

As counterintuitive as it may seem, most knees respond well to just being up and about and not folded up under you on a sofa all day. Combine that with natural anti-inflammatories such as cod liver oil and turmeric, and you'll hit the REAL jackpot -- side-effect free pain relief.

With news your knees need,

William Campbell Douglass II, M.D. 
I located the full study he referred to:  Arthroscopic surgery for degenerative knee: systematic review and meta-analysis of benefits and harms (doi: 10.1136/bmj.h2747).

Here are a couple of other reports on the study:
This is Dr. Douglass' second report ─ the one concerning body-fat types:

'Brown breakthrough' is the secret to burning off blubber FAST
Somewhere along the way, you picked up a spare tire.

For most folks, it starts out as a little jiggle in the middle somewhere around middle age. By the time you hit your 50s or 60s, it's a full blown spare -- maybe even a snow tire -- and it seems like nothing you do will take the air out.

You'd think the last thing you'd want is to build up even MORE fat in your body. But as it turns out, a little extra fat is exactly what you need... as long as it's the right kind.

You see you've got two kinds of fat, the jelly belly white blubber that piles up around your middle and the ultra-efficient, calorie-burning brown fat that uses the white stuff for fuel.

As you age you lose your brown fat and the white stuff piles up.

But the latest research shows you can transform some of your white fat into beige, a state in between the two forms of fat that acts more like brown fat -- burning off the blubber so you can see your shoes again.

You've heard of resveratrol, the age-fighting, disease-beating polyphenol found in fruit such as grapes and berries. It's been nicknamed "the fountain of youth" because this stuff may literally help extend your life.

But before it adds pages to your calendar, it can help subtract fat from your waistline -- because the new study reveals resveratrol can ignite a process called browning, which converts useless white fat into that calorie-burning beige variety.

Two sets of mice were put on a diet designed to turn them into butterballs. But one group got a little bonus mixed in with their mouse chow: resveratrol. Despite being on the same diet, the lucky squeakers that got the resveratrol gained 40 percent less weight, and the researchers say it's because their white fat turned to beige.

Yes, the study was on mice and not people so it's not the last word on this. But since resveratrol packs dozens of other benefits, there's certainly no harm in trying it.

To get the equivalent human amount used in the study, you'd have to eat about 12 ounces of resveratrol-rich fruit such as berries and grapes per day. If that's a little too much sugar for you, try a supplement instead.

And that's not the only way to get the job done. ... 
It may not be the only method to effect the change, but the good doctor does not actually say in that report just what the other pathways are.

I located the official source for the published study, but only the abstract or summary is available to the general public without payment of a fee:  Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1 (doi: 10.1038/ijo.2015.23).

However, one of the authors is Min Du of Washington State University, and he has made the full report available at ResearchGate.net here.  It seems that the other researchers listed as being involved with the study also have the publication available under their own profiles at ResearchGate.

Anyway, here are a couple of other reports about the study:
Unfortunately for me, resveratrol is one of the supplements that I had to forsake soon after retiring in April 2011 because I just could not afford it.

If you think you can handle a little heavy-duty reading concerning a GM trial, then the published study in this reference from theSparc.net was made for you!
Results from the controversial GM wheat trial in the UK has been published by Bruce et al., (2015), showing that the new GM wheat did not repel aphid pests any more than control plants. The GM wheat expresses an aphid alarm pheromone that in nature, serves to repel aphids and attract their natural enemies. When the pheromone was put into the plant, the insects showed rapid habituation to the pheromone in the field trials, exposing the crude principles of this form of pest control.
So basically, we have a food item that has been genetically modified, and which may ─ over time ─ prove harmful to those of us who consume it (as well as the other living creatures that may consume it)...yet its genetic modification has actually proven a failure where the modification's purpose is concerned:  "...field trials employing the single and double constructs showed no reduction in aphids or increase in parasitism."

Of course, we needn't concern ourselves over any of this ─ authorities who know everything have assured that the trial posed no threat:
Permission for the trials was granted in Sept 2011 by Defra (Department of Environment, Food and Rural Affairs) after an assessment of the risks to human health and the environment, a period of public consultation and advice from ACRE (the Advisory Committee on Releases in the Environment).
What a relief that such authorities know all concerning potential GM harm "to human health and the environment!"

The smoke lifted enough for awhile during the afternoon that it became a haze, with the Sun managing to throw its glow here to the Earth.

So in the mid-afternoon, I sunned my back and my front while donned in just a pair of shorts ─ at least 20 minutes a side.

I have often mentioned the wasp nest ─ nearly the size of a small grapefruit ─ located in the backyard shed.  Its inhabitants never seem threatened or even bothered by me; and anytime I have the door unlocked and opened, an occasional wasp will figure out that easy exit and leisurely drift on out to do whatever it is that wasps do ─ seek insect prey, I expect.

Well, it occurred to me this afternoon that their death toll is likely very high in the stifling, small shed.  Believe it or not, I am considering leaving the door open for several hours a day as of tomorrow.

I know they get in and out of there somehow ─ the place is not airtight, after all.  But the traffic is extremely limited.  As I said, I have only ever seen a few use the open door even when it might be open for as many as 10 minutes.

By comparison, there is a wasp nest somewhere in the board-work helping to form a slightly raised garden bed under the living room window at the front of the house.  Those wasps are nearly a steady stream of traffic, going to and coming from the nest. 

I spent about 30 seconds trying to capture photos of them, but they are so swift ─ they know exactly where the crevice in the wood is and fly directly into their entrance.

I only managed these three shots of actual wasps out of the 12 photos that I took in that span of 30 or so seconds ─ their opening is a space between the left topmost length of wood, and the left section beneath it.  They are not using that visible cave-like hole between the bottom length of wood and the ground.

Each of these photos has a wasp visible in flight, so look carefully:

In the 30 or so seconds that I was trying to capture wasps in my photographs, there were likely just as many wasps that had come to or gone from the hidden nest.

Yet as I said, the poor souls in the shed might have two or three members of the colony use the open door in a space of time that might be as long as 10 minutes.

The shed wasps never bother me ─ I have even had the occasional wasp circle right around me to get out of or into the shed, treating me simply as an obstacle it needs to bypass.

So maybe I'll lend them a wee bit of help by leaving the door open for several hours a day ─ unless I notice the nest suddenly becoming too large too fast.

I now close  today's post with a short entry from my journal of 41 years ago when I was 24 years old, and living in a cheap housekeeping room in New Westminster.
SATURDAY, July 6, 1974

I went sunning at Burnaby Lake today.  I planned to bath early, but the landlord's open door cowed me; thus, my hope of getting to the Russell early and searching out Mark and Cathy came to naught.

Before heading for the lake, I did my laundry, and even bought a Pioneer canvas water bag ($3.19) at Woodwards.
The hike to reach Burnaby Lake and then return home again was considerable from where I lived at (I think) 333 Pine Street.  I would go to that effort to sun simply because I was still too backward to expose myself publicly at a local park ─ I could seclude myself in some hidden wooded section of the lake.

The caretaker had expressed considerable censure to me in the past for my 'frequent' use of the bath tub ─ the bathroom was a communal affair, so anytime someone was using it, obviously no one else would be able to.

Pity anyone with bad bowels!

The Russell Hotel was a popular drinking establishment.  I evidently had hoped to get to it and maybe link up with my younger brother Mark and his girlfriend Catherine Jeanette Gunther.

Even though they shared a rented home together out in Whalley, the Russell was still the best place to go at that time to drink publicly.

I had to launder at a laudromat.

That Pioneer canvas water bag ─ I may still own the darned thing!  If so, it lasted better than did Woodward's department store.  They no longer exist ─ in New Westminster, or anywhere else, I guess.
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